Ozempic vs Mounjaro (Semaglutide vs Tirzepatide) for Weight Loss in Adults: A Comprehensive Comparison (2023)

Guntipalli Praveen


March 28, 2023

Ozempic vs Mounjaro (Semaglutide vs Tirzepatide) for Weight Loss in Adults: A Comprehensive Comparison (2)

The struggle with obesity and weight loss has long been a topic of concern for many individuals. With advancements in medical science, new medications have been introduced to aid in weight management. Semaglutide and tirzepatide are two game-changing and revolutionary drugs in this field. In this article, we will compare these medications, discuss their mechanisms of action, efficacy, and side effects, and provide insights on choosing the right weight loss medication for you.

Are you unsure about your weight status? Check your BMI here. BMI stands for Body Mass Index, which is a measure of body fat based on height and weight. It is used to classify whether a person is underweight, normal weight, overweight, or obese.

Determine your BMIand its related weight status category with this free calculator, designed specifically for adults over 20 years of age.

Here are the categories for BMI based on the World Health Organization (WHO) classification system:

  • Underweight: BMI less than 18.5
  • Normal weight: BMI between 18.5 and 24.9
  • Overweight: BMI between 25 and 29.9
  • Obesity: BMI of 30 or higher


Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist initially developed for the treatment of type 2 diabetes. It has recently gained attention as a weight loss medication due to its appetite-suppressing effects. Semaglutide has been approved by the FDA for weight loss. Specifically, the FDA approved semaglutide for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity such as high blood pressure, type 2 diabetes, or high cholesterol. The approval was granted on June 4, 2021, for a once-weekly injectable dose of semaglutide under the brand name Wegovy

(Video) Mounjaro (Tirzepatide) Vs Ozempic (Semaglutide) For Weight Loss & Diabetes Management

How Semaglutide Works

Semaglutide works by mimicking the action of GLP-1, a hormone released by the gut after eating. This hormone slows down the emptying of the stomach and increases insulin secretion, leading to a reduction in appetite and blood sugar levels. Consequently, individuals taking semaglutide tend to consume fewer calories and lose weight.

Efficacy and Side Effects

Studies have shown that semaglutide is effective in promoting significant weight loss in both diabetic and non-diabetic patients. Some common side effects of this medication include nausea, vomiting, diarrhea, and constipation, which typically lessen over time.

Contraindications for semaglutide:

  1. Hypersensitivity: Individuals who have had a severe allergic reaction to semaglutide or any of its components, including known hypersensitivity to OZEMPIC, should not use the medication.
  2. History of pancreatitis: Semaglutide may increase the risk of pancreatitis, so it is not recommended for people with a history of this condition.
  3. Diabetic ketoacidosis (DKA): Semaglutide is not suitable for the treatment of DKA and should not be used in patients experiencing this condition.
  4. Type 1 diabetes: Semaglutide is not approved for use in individuals with type 1 diabetes, as its safety and efficacy in this population have not been established.
  5. Pregnancy: Semaglutide is not recommended for use during pregnancy, as its safety for pregnant women and unborn babies is not well-established. Healthcare providers may evaluate the potential benefits and risks on a case-by-case basis.
  6. Personal or family history of medullary thyroid carcinoma: Semaglutide is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma (MTC).
  7. Multiple Endocrine Neoplasia syndrome type 2 (MEN 2): Patients with Multiple Endocrine Neoplasia syndrome type 2 should not use semaglutide due to the potential risk of MTC.


Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is currently under development for the treatment of type 2 diabetes. It has also shown promise as a weight loss medication. Tirzepatide had not yet received FDA approval for weight loss as of March 27, 2023

How Tirzepatide Works

Tirzepatide works by stimulating both GIP and GLP-1 receptors. This dual action leads to improved blood sugar control, increased insulin secretion, slowed gastric emptying, and reduced appetite. As a result, individuals taking tirzepatide can experience weight loss.

Efficacy and Side Effects

Clinical trials have demonstrated that tirzepatide is effective in reducing body weight and improving glycemic control in patients with type 2 diabetes. The side effects of tirzepatide are similar to those of semaglutide, including nausea, vomiting, diarrhea, and constipation. However, these side effects often subside over time as the body adjusts to the medication.

Contraindications for tirzepatide share similarities with those of semaglutide.

Semaglutide vs Tirzepatide: Similarities and Differences

Now that we have a basic understanding of both medications, let's compare them based on their mechanism of action, efficacy in weight loss, and side effects.

Mechanism of Action

Both semaglutide and tirzepatide are injectable medications that work by affecting hormones involved in appetite regulation and blood sugar control. While semaglutide is a GLP-1 receptor agonist, tirzepatide is a dual GIP and GLP-1 receptor agonist, offering a potentially enhanced effect on weight loss and glycemic control.

Efficacy in Weight Loss

Clinical trials have shown that both semaglutide and tirzepatide can lead to significant weight loss in individuals with type 2 diabetes. However, tirzepatide appears to be more effective, with patients losing more weight compared to those taking semaglutide. It is essential to note that the results may vary among individuals, and further research is needed to determine the long-term effects of these medications on weight management.

Side Effects and Safety

Both medications have similar side effects, including gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation. These side effects often diminish as the body adjusts to the medication. Overall, both semaglutide and tirzepatide are considered safe for use, but it is crucial to consult a healthcare professional before starting any weight loss medication.

Results from studies compared

Semaglutide Clinical trial:

The mean change in body weight from baseline to week 68 was −14.9% in the semaglutide group as compared with −2.4% with placebo, for an estimated treatment difference of −12.4 percentage points (95% confidence interval [CI], −13.4 to −11.5; P<0.001).

Tirzepatide Clinical trial:

The mean percentage change in weight at week 72 was −15.0% (95% confidence interval [CI], −15.9 to −14.2) with 5-mg weekly doses of tirzepatide, −19.5% (95% CI, −20.4 to −18.5) with 10-mg doses, and −20.9% (95% CI, −21.8 to −19.9) with 15-mg doses and −3.1% (95% CI, −4.3 to −1.9) with placebo (P<0.001 for all comparisons with placebo).

Additional research, including randomized double-blind studies, is necessary to further compare both medications.

Ozempic vs Mounjaro (Semaglutide vs Tirzepatide) for Weight Loss in Adults: A Comprehensive Comparison (3)Ozempic vs Mounjaro (Semaglutide vs Tirzepatide) for Weight Loss in Adults: A Comprehensive Comparison (4)

(Video) Mounjaro vs Wegovy: The Showdown for Diabetes and Weight Loss

Factors to Consider When Choosing a Weight Loss Medication

When deciding between semaglutide and tirzepatide for weight loss, several factors should be considered:

Health Condition

Your overall health and the presence of any underlying medical conditions, such as type 2 diabetes or cardiovascular disease, should be taken into account when selecting a weight loss medication. Always consult with a healthcare professional to determine the most appropriate medication for your specific situation.

Physician's Recommendation

Your doctor's recommendation plays a significant role in choosing the right medication. They will consider your medical history, current health status, and potential drug interactions before suggesting the most suitable option for you.

Lifestyle Factors

Lifestyle factors, such as diet, exercise, and stress management, should also be considered when selecting a weight loss medication. Remember that medications like semaglutide and tirzepatide are meant to be used in conjunction with a healthy diet and regular physical activity to achieve optimal results.

Additional Considerations

While semaglutide and tirzepatide are promising weight loss medications, it is important to remember that they are not a one-size-fits-all solution. Weight loss is a complex process influenced by various factors such as genetics, metabolism, lifestyle choices, and mental health. Medications like semaglutide and tirzepatide should be considered as part of a comprehensive weight management plan that includes a balanced diet, regular exercise, and support from healthcare professionals.

(Video) Mounjaro (Tirzepatide) vs Ozempic (Semaglutide) for Weight Loss

The Importance of a Holistic Approach to Weight Loss

When considering weight loss medications, it is vital to adopt a holistic approach that addresses the root causes of weight gain and promotes sustainable, long-term weight loss. This may involve exploring emotional eating, stress management, and sleep hygiene, in addition to dietary and exercise changes. By addressing the underlying factors contributing to weight gain, individuals are more likely to achieve lasting weight loss success.

Seeking Professional Guidance

If you are struggling with weight loss and considering semaglutide or tirzepatide, it is highly recommended to consult with a healthcare professional who is board certified in Obesity Medicine. They can evaluate your specific situation, help you develop a personalized weight management plan, and provide guidance on the use of weight loss medications in conjunction with lifestyle changes. This collaborative approach will increase the likelihood of achieving and maintaining a healthy weight.


Both semaglutide and tirzepatide show promise as weight loss medications. While they share similarities in their mechanisms of action and side effects, tirzepatide appears to be more effective in promoting weight loss. However, individual results may vary, and it is essential to consult a healthcare professional before starting any weight loss medication. Factors such as health condition, physician's recommendation, and lifestyle factors should be considered when making a decision.


  1. Can I take semaglutide or tirzepatide without a prescription?

No, both medications require a prescription from a healthcare professional.

2. Are semaglutide and tirzepatide only for individuals with type 2 diabetes?

While both medications were initially developed for the treatment of type 2 diabetes, they have shown promise in promoting weight loss in non-diabetic individuals as well. However, it is crucial to consult a healthcare professional before starting any weight loss medication.

  1. Can I stop taking semaglutide or tirzepatide once I achieve my desired weight?

Discontinuing any weight loss medication should be done under the guidance of a healthcare professional. They will help you develop a plan to maintain your weight loss through lifestyle changes, such as diet and exercise.

  1. Do semaglutide and tirzepatide interact with other medications?

Both medications can potentially interact with other drugs, so it is important to inform your healthcare provider about all medications you are currently taking.

  1. How long does it take to see weight loss results with semaglutide or tirzepatide?

Weight loss results may vary between individuals, but some patients may notice improvements within a few weeks of starting the medication. It is essential to follow your healthcare provider's recommendations and maintain a healthy lifestyle for optimal results


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1. Mounjaro (tirzepatide): The newest diabetes and obesity medication (explanation and overview)
(Christopher McGowan, MD)
2. ADA 2021 – SURPASS-2: Tirzepatide versus semaglutide in type 2 diabetes | Juan Pablo Frías
(Medicine Matters diabetes)
3. Doctors explain how Wegovy and Ozempic work | 60 Minutes
(60 Minutes)
4. New Obesity meds? Could Ozempic or Wegovy no longer be the King of the Hill?
(Dr. Dan | Obesity Expert)
5. ADA 2021 – The SURPASS trials so far: Tirzepatide, semaglutide, and type 2 diabetes | John Wilding
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6. 'Game changer' painless injections to shed pounds | Weight Loss Wednesday


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