donepezil and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and amisulpride both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.
donepezil and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and artemether both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine transdermal and donepezil both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and bedaquiline both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine buccal and donepezil both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine subdermal implant and donepezil both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine transdermal and donepezil both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine, long-acting injection and donepezil both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and ceritinib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and chloroquine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and citalopram both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and crizotinib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and droperidol both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and encorafenib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and eribulin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.
fexinidazole and donepezil both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.
donepezil and flecainide both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and histrelin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and ivosidenib both decrease QTc interval. Avoid or Use Alternate Drug.
lefamulin and donepezil both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and lithium both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and methadone both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and mobocertinib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and ondansetron both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and ozanimod both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and pimozide both increase QTc interval. Contraindicated.
donepezil and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.
ponesimod, donepezil.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Consult cardiologist if considering treatment. Coadministration of ponesimod with drugs that decrease HR may have additive effects on decreasing HR and should generally not be initiated in these patients.donepezil and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and procainamide both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and propafenone both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and quetiapine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and quinidine both increase QTc interval. Contraindicated.
donepezil and quinine both increase QTc interval. Avoid or Use Alternate Drug.
ribociclib will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.donepezil and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and selpercatinib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and sevoflurane both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and siponimod both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and sorafenib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and sotalol both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and toremifene both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
triamcinolone acetonide injectable suspension, donepezil. unspecified interaction mechanism. Avoid or Use Alternate Drug. Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If possible, withdraw anticholinesterase agents at least 24 hours before initiating corticosteroid therapy.
donepezil and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.
donepezil increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and albuterol both increase QTc interval. Use Caution/Monitor.
donepezil and alfuzosin both increase QTc interval. Use Caution/Monitor.
amifampridine and donepezil both increase cholinergic effects/transmission. Use Caution/Monitor.
donepezil increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.donepezil and amitriptyline both increase QTc interval. Use Caution/Monitor.
donepezil increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and anticholinergic/sedative combos decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and apomorphine both increase QTc interval. Use Caution/Monitor.
donepezil and arformoterol both increase QTc interval. Use Caution/Monitor.
donepezil and aripiprazole both increase QTc interval. Use Caution/Monitor.
artemether/lumefantrine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
donepezil and atomoxetine both increase QTc interval. Use Caution/Monitor.
donepezil increases and atracurium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and atropine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and atropine IV/IM decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
donepezil increases and belladonna alkaloids decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and belladonna and opium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil decreases effects of benztropine by pharmacodynamic antagonism. Use Caution/Monitor.
bethanechol and donepezil both increase cholinergic effects/transmission. Use Caution/Monitor.
carbachol and donepezil both increase cholinergic effects/transmission. Use Caution/Monitor.
carbamazepine will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
cevimeline and donepezil both increase cholinergic effects/transmission. Use Caution/Monitor.
cimetidine will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil and ciprofloxacin both increase QTc interval. Use Caution/Monitor.
donepezil and cisapride both increase QTc interval. Use Caution/Monitor.
donepezil increases and cisatracurium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
clarithromycin will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil increases and clomipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezil and clomipramine both increase QTc interval. Use Caution/Monitor.
donepezil and clozapine both increase QTc interval. Use Caution/Monitor.
donepezil increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and cyclobenzaprine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and darifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and dasatinib both increase QTc interval. Use Caution/Monitor.
donepezil and degarelix both increase QTc interval. Use Caution/Monitor.
donepezil and desipramine both increase QTc interval. Use Caution/Monitor.
desvenlafaxine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mg
donepezil and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).
dichlorphenamide and donepezil both decrease serum potassium. Use Caution/Monitor.
donepezil increases and dicyclomine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
diltiazem will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and dolasetron both increase QTc interval. Use Caution/Monitor.
donepezil increases and dosulepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and doxepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezil and doxepin both increase QTc interval. Use Caution/Monitor.
donepezil and echothiophate iodide both increase cholinergic effects/transmission. Use Caution/Monitor.
efavirenz will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil and eliglustat both increase QTc interval. Use Caution/Monitor.
erythromycin base will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
erythromycin ethylsuccinate will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
erythromycin lactobionate will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
erythromycin stearate will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil and escitalopram both increase QTc interval. Use Caution/Monitor.
donepezil increases and fesoterodine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fingolimod and donepezil both increase QTc interval. Use Caution/Monitor.
donepezil increases and flavoxate decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and fluconazole both increase QTc interval. Use Caution/Monitor.
fluoxetine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.donepezil and fluoxetine both increase QTc interval. Use Caution/Monitor.
donepezil and fluphenazine both increase QTc interval. Use Caution/Monitor.
donepezil and fluvoxamine both increase QTc interval. Use Caution/Monitor.
donepezil and formoterol both increase QTc interval. Use Caution/Monitor.
donepezil and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.
donepezil and galantamine both increase cholinergic effects/transmission. Use Caution/Monitor.
donepezil and gemifloxacin both increase QTc interval. Use Caution/Monitor.
donepezil and gemtuzumab both increase QTc interval. Use Caution/Monitor.
donepezil and gilteritinib both increase QTc interval. Use Caution/Monitor.
donepezil increases and glycopyrrolate decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and glycopyrrolate inhaled decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and goserelin both increase QTc interval. Use Caution/Monitor.
donepezil and granisetron both increase QTc interval. Use Caution/Monitor.
donepezil and haloperidol both increase QTc interval. Use Caution/Monitor.
donepezil increases and henbane decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and homatropine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and huperzine A both increase cholinergic effects/transmission. Use Caution/Monitor.
donepezil and hydroxyzine both increase QTc interval. Use Caution/Monitor.
donepezil increases and hyoscyamine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and hyoscyamine spray decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
donepezil increases and imipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezil and imipramine both increase QTc interval. Use Caution/Monitor.
donepezil and indacaterol, inhaled both increase QTc interval. Use Caution/Monitor.
donepezil increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and itraconazole both increase QTc interval. Use Caution/Monitor.
ketoconazole will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil and lapatinib both increase QTc interval. Use Caution/Monitor.
letermovir increases levels of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil and leuprolide both increase QTc interval. Use Caution/Monitor.
donepezil and levalbuterol both increase QTc interval. Use Caution/Monitor.
donepezil and levofloxacin both increase QTc interval. Use Caution/Monitor.
levoketoconazole will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil increases and lofepramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and loperamide both increase QTc interval. Use Caution/Monitor.
lumefantrine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
donepezil increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezil and maprotiline both increase QTc interval. Use Caution/Monitor.
donepezil increases and meclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and mefloquine both increase QTc interval. Use Caution/Monitor.
donepezil increases and methscopolamine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and mifepristone both increase QTc interval. Use Caution/Monitor.
donepezil and mirtazapine both increase QTc interval. Use Caution/Monitor.
donepezil and neostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.
donepezil increases and nortriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezil and nortriptyline both increase QTc interval. Use Caution/Monitor.
donepezil and octreotide both increase QTc interval. Use Caution/Monitor.
donepezil and ofloxacin both increase QTc interval. Use Caution/Monitor.
donepezil and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances
donepezil and olodaterol inhaled both increase QTc interval. Use Caution/Monitor.
donepezil increases and onabotulinumtoxinA decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and orphenadrine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
osilodrostat and donepezil both increase QTc interval. Use Caution/Monitor.
donepezil increases and oxybutynin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and oxybutynin topical decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and oxybutynin transdermal decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and pancuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
paroxetine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.donepezil and paroxetine both increase QTc interval. Use Caution/Monitor.
donepezil and pasireotide both increase QTc interval. Use Caution/Monitor.
donepezil and perphenazine both increase QTc interval. Use Caution/Monitor.
donepezil and physostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.
donepezil and pilocarpine both increase cholinergic effects/transmission. Use Caution/Monitor.
donepezil and posaconazole both increase QTc interval. Use Caution/Monitor.
donepezil increases and pralidoxime decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and primaquine both increase QTc interval. Use Caution/Monitor.
donepezil and prochlorperazine both decrease QTc interval. Use Caution/Monitor.
donepezil and promethazine both decrease QTc interval. Use Caution/Monitor.
donepezil increases and propantheline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and protriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezil and protriptyline both increase QTc interval. Use Caution/Monitor.
donepezil and pyridostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.
quinidine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
donepezil will increase the level or effect of ramelteon by unspecified interaction mechanism. Use Caution/Monitor. AUC and Cmax increased by 100% and 87% respectively.
donepezil and ranolazine both increase QTc interval. Use Caution/Monitor.
donepezil increases and rapacuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
rifabutin will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
rifampin will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil and rilpivirine both increase QTc interval. Use Caution/Monitor.
donepezil and risperidone both increase QTc interval. Use Caution/Monitor.
donepezil and rivastigmine both increase cholinergic effects/transmission. Use Caution/Monitor.
donepezil increases and rocuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and romidepsin both increase QTc interval. Use Caution/Monitor.
donepezil and salmeterol both increase QTc interval. Use Caution/Monitor.
donepezil increases and scopolamine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and sertraline both increase QTc interval. Use Caution/Monitor.
donepezil increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
St John's Wort will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
donepezil and succinylcholine both increase cholinergic effects/transmission. Use Caution/Monitor.
donepezil and sunitinib both increase QTc interval. Use Caution/Monitor.
donepezil and tacrolimus both increase QTc interval. Use Caution/Monitor.
donepezil and telavancin both increase QTc interval. Use Caution/Monitor.
donepezil increases and tiotropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil increases and tolterodine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and triclabendazole both increase QTc interval. Use Caution/Monitor.
donepezil and trifluoperazine both decrease QTc interval. Use Caution/Monitor.
donepezil decreases effects of trihexyphenidyl by pharmacodynamic antagonism. Use Caution/Monitor.
donepezil increases and trimipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and triptorelin both increase QTc interval. Use Caution/Monitor.
donepezil increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. Use Caution/Monitor.
valbenazine and donepezil both increase QTc interval. Use Caution/Monitor.
donepezil and vardenafil both increase QTc interval. Use Caution/Monitor.
donepezil increases and vecuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
donepezil and venlafaxine both decrease QTc interval. Use Caution/Monitor.
donepezil and vilanterol/fluticasone furoate inhaled both increase QTc interval. Use Caution/Monitor.
donepezil and voclosporin both increase QTc interval. Use Caution/Monitor.
donepezil and voriconazole both increase QTc interval. Use Caution/Monitor.
donepezil and vorinostat both increase QTc interval. Use Caution/Monitor.
donepezil decreases effects of aclidinium by pharmacodynamic antagonism. Minor/Significance Unknown.
amiodarone will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
amobarbital will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of anticholinergic/sedative combos by pharmacodynamic antagonism. Minor/Significance Unknown.
aprepitant will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
armodafinil will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
artemether/lumefantrine will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
asenapine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
atazanavir will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of atracurium by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of atropine by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of atropine IV/IM by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of belladonna alkaloids by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of belladonna and opium by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil increases effects of bethanechol by pharmacodynamic synergism. Minor/Significance Unknown.
bosentan will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
budesonide will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
bupropion will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
butabarbital will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
butalbital will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil increases effects of carbachol by pharmacodynamic synergism. Minor/Significance Unknown.
celecoxib will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil increases effects of cevimeline by pharmacodynamic synergism. Minor/Significance Unknown.
chloroquine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
cimetidine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil decreases effects of cisatracurium by pharmacodynamic antagonism. Minor/Significance Unknown.
conivaptan will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
cortisone will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of cyclizine by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of cyclobenzaprine by pharmacodynamic antagonism. Minor/Significance Unknown.
cyclosporine will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
darifenacin will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.darifenacin will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.donepezil decreases effects of darifenacin by pharmacodynamic antagonism. Minor/Significance Unknown.
darunavir will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
dasatinib will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
deferasirox will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil increases and desipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
dexamethasone will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
DHEA, herbal will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of dicyclomine by pharmacodynamic antagonism. Minor/Significance Unknown.
diphenhydramine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.donepezil decreases effects of diphenhydramine by pharmacodynamic antagonism. Minor/Significance Unknown.
dronedarone will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.dronedarone will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
duloxetine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil increases effects of echothiophate iodide by pharmacodynamic synergism. Minor/Significance Unknown.
eslicarbazepine acetate will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
etravirine will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of fesoterodine by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of flavoxate by pharmacodynamic antagonism. Minor/Significance Unknown.
fluconazole will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
fludrocortisone will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
fosamprenavir will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
fosaprepitant will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
fosphenytoin will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil increases effects of galantamine by pharmacodynamic synergism. Minor/Significance Unknown.
donepezil decreases effects of glycopyrrolate by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of glycopyrrolate inhaled by pharmacodynamic antagonism. Minor/Significance Unknown.
grapefruit will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
griseofulvin will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
haloperidol will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil decreases effects of henbane by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of homatropine by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil increases effects of huperzine A by pharmacodynamic synergism. Minor/Significance Unknown.
hydrocortisone will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of hyoscyamine by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of hyoscyamine spray by pharmacodynamic antagonism. Minor/Significance Unknown.
imatinib will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
indinavir will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of ipratropium by pharmacodynamic antagonism. Minor/Significance Unknown.
isoniazid will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
lapatinib will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
lumefantrine will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
maraviroc will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
marijuana will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.marijuana will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of meclizine by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of methscopolamine by pharmacodynamic antagonism. Minor/Significance Unknown.
methylprednisolone will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
metronidazole will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
miconazole vaginal will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
nefazodone will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
nelfinavir will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil increases effects of neostigmine by pharmacodynamic synergism. Minor/Significance Unknown.
nevirapine will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
nifedipine will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
nilotinib will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.nilotinib will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Minor/Significance Unknown.
oxcarbazepine will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of oxybutynin by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of oxybutynin topical by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of oxybutynin transdermal by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of pancuronium by pharmacodynamic antagonism. Minor/Significance Unknown.
pantothenic acid, donepezil.Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
parecoxib will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
pentobarbital will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
perphenazine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
phenobarbital will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
phenytoin will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil increases effects of physostigmine by pharmacodynamic synergism. Minor/Significance Unknown.
donepezil increases effects of pilocarpine by pharmacodynamic synergism. Minor/Significance Unknown.
posaconazole will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of pralidoxime by pharmacodynamic antagonism. Minor/Significance Unknown.
prednisone will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
primidone will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
procainamide decreases effects of donepezil by pharmacodynamic antagonism. Minor/Significance Unknown.
propafenone will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil decreases effects of propantheline by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil increases effects of pyridostigmine by pharmacodynamic synergism. Minor/Significance Unknown.
quinacrine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
quinupristin/dalfopristin will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
ranolazine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil decreases effects of rapacuronium by pharmacodynamic antagonism. Minor/Significance Unknown.
rifapentine will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
ritonavir will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.ritonavir will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of rocuronium by pharmacodynamic antagonism. Minor/Significance Unknown.
rufinamide will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil decreases effects of scopolamine by pharmacodynamic antagonism. Minor/Significance Unknown.
secobarbital will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
sertraline will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil decreases effects of solifenacin by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil increases effects of succinylcholine by pharmacodynamic synergism. Minor/Significance Unknown.
thioridazine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil decreases effects of tiotropium by pharmacodynamic antagonism. Minor/Significance Unknown.
tipranavir will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
donepezil decreases effects of tolterodine by pharmacodynamic antagonism. Minor/Significance Unknown.
topiramate will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
donepezil increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
donepezil decreases effects of trospium chloride by pharmacodynamic antagonism. Minor/Significance Unknown.
donepezil decreases effects of vecuronium by pharmacodynamic antagonism. Minor/Significance Unknown.
venlafaxine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
verapamil will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
voriconazole will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
zafirlukast will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.